Research Publications

34. Chaulk, S.G.; MacMillan, A.M. "Unusual Hydrolytic Chemistry at the Heart of the Mammalian Spliceosome" submitted.

33. Ritchie, D.B., Schellenberg, M.J., MacMillan, A.M. "Spliceosome Struicture: Piece by Piece" Biochim. Biophys. Acta 1789 624-633 (2009). [pdf file]

32. Kent, O.A.; MacMillan, A.M. "Proteins Specifically Modified with a Chemical Nuclease as Probes of RNA-Protein Interaction" in Methods Mol. Biol. 488 191-200 RNA-Protein Interaction Protocols, second edition (R.J. Lin, Ed.; Humana Press, Totowa, N.J., 2008). [pdf file on request]

31. Ritchie, D.B., Schellenberg, M.J., Gesner, E.M., Raithatha S.A., Stuart, D.T., MacMillan, A.M. "Structural elucidation of a PRP8 core domain from the heart of the spliceosome" Nature Struct. Mol. Biol. 15 1199-1205 (2008). [pdf file] [Supplementary pdf file]

30. Schellenberg, M.J.; Ritchie, D.B.; MacMillan, A.M. "Pre-mRNA splicing: a complex picture in higher definition" TiBS 33 243-246 (2008). [pdf file on request]

29. Chaulk, S.G.; MacMillan, A.M. "Synthesis of oligo-RNAs with photocaged adenosine 2'-hydroxyls" Nature Protocols 2 1052-1058 (2007). [pdf file]

28. Chilibeck, K.A.; Wu, T.; Liang, C.; Schellenberg, M.J.; Gesner, E.M.; Lynch, J.M.; MacMillan. A.M. "FRET Analysis of In Vivo Dimerization by RNA Editing Enzymes" J. Biol. Chem. 281 16530-16535 (2006). [pdf file]

27. Schellenberg, M.J.; Edwards, R.A.; Ritchie, D.B.; Oliver A. Kent, O.A.; Golas, M.M.; Stark, H.; Luhrmann, R.; Glover, J.N.M.; MacMillan, A.M. "Crystal Structure of a Core Spliceosomal Protein Interface" Proc. Natl. Acad. Sci. U.S.A. 5 1266-1271 (2006). [pdf file]

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26. Chaulk, S.G.; Kent, O.A.; MacMillan, A.M. "Photo-control of RNA Processing" in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules, (Goeldner, M. , Givens, R. Eds.), pp. 495-513 (Wiley-VCH Weinham, 2005). [pdf file]

25. Kent, O.A.; Ritchie, D.B.; MacMillan, A.M. "E': A Novel Commitment Complex in the Mammalian Spliceosome Assembly Pathway" Mol. Cell. Biol. 25 233-240 (2005). [pdf file] .

24. MacMillan, A.M. "Fifty Years of "Watson-Crick"" Pure Appl. Chem. 76, 1521-1524 (2004). [pdf file]

23. Kent, O.A.; MacMillan, A.M. "RNAi: Running Interference for the Cell" Org. Biomol. Chem. 2 1957-1961 (2004). [pdf file on request]

22. Kent, O.A.; Reayi, A.; Foong L.; Chilibeck K.A.; MacMillan, A.M. "Structuring of the 3' Splice Site by U2AF65" J. Biol. Chem. 278 50572-50577 (2003). [pdf file]

21. Jaikaran, D.C.J.; Collins, C.H.; MacMillan, A.M. "Adenosine to Inosine Editing by ADAR2 Requires Formation of a Ternary Complex on the GluR-B R/G Site" J. Biol. Chem. 277 37624-37629 (2002). [pdf file]

20. Kent, O.; MacMillan, A.M. "Early Organization of pre-mRNA During Spliceosome Assembly" Nature Struct. Biol. 9 576-581 (2002). [pdf file]

19. MacMillan, A.M. "From Equilibrium to Kinetic Footprinting of RNA Structure" J. Chem. Soc. Perkin Trans. 2, 8 1263-1267 (2001). [pdf file]

18. Chaulk, S.G.; MacMillan, A.M. "Separation of Spliceosome Assembly from Catalysis Using Caged pre-mRNA Substrates" Angew. Chemie Int. Ed., 40 2149-2152 (2001)/Angew. Chemie, 113 2207-2210 (2001). [pdf file]

17. Will, C.L.; Schneider, C.; MacMillan, A.M.; Katopodis, N.; Neubauer, G.; Wilm, M.; Lührmann, R.; Query, C.C. "A Novel U2 and U11/U12 snRNP Protein that Associates with the pre-mRNA Branch Site" EMBO J., 20 4536-4546 (2001). [pdf file]

16. Kent, O.; Chaulk, S.G.; MacMillan, A.M. "Kinetic Analysis of the M1 RNA Folding Pathway"J. Mol. Biol. 304 699-705 (2000). [pdf file]

15. Chaulk, S.G.; Pezacki, J.P.; MacMillan, A.M. "Development of a New Photochemical Footprinting Method. Studies of RNA Cleavage by Photolysis of N-Hydroxypyridine-2(1H)-thione" Biochemistry 39 10448-10453 (2000). [pdf file]

14. Jaikaran, D.C.J.; MacMillan, A.M. "Template-Directed Interference Footprinting for RNA Based on Inosine Specific Cleavage" Bioorg. Med. Chem. Lett. 10 1633-1635 (2000). [pdf file]

13. Chaulk, S.G.; MacMillan, A.M. "Kinetic Footprinting of an RNA Folding Pathway Using Peroxynitrous Acid" Angew. Chemie Int. Ed., 39 521-523 (2000)/Angew. Chemie, 112 531-533 (2000). [pdf file]

12. Chaulk, S.G.; MacMillan, A.M. "Characterization of the Tetrahymena Ribozyme Folding Pathway Using the Kinetic Footprinting Reagent Peroxynitrous Acid" Biochemistry, 39 2-8 (2000). [pdf file]

11. Pomeranz Krummel, D.A.; Kent, O.; MacMillan, A.M.; Altman, S. "Evidence for Helical Unwinding of an RNA Substrate by the RNA Enzyme RNase P: Use of an Interstrand Disulfide Crosslink in Substrate" J. Mol. Biol., 295 1113-1118 (2000). [pdf file]

10. Chaulk, S.G.; MacMillan, A.M. "Caged RNA: Photo-control of a Ribozyme Reaction" Nucleic Acids Res., 26 3173-3178 (1998). [pdf file]

9. MacMillan, A.M.; McCaw, P.S.; Crispino, J.D.; Sharp, P.A. "SC35 Mediated Reconstitution of Splicing in U2AF Depleted Nuclear Extract" Proc. Natl. Acad. Sci. U.S.A., 94 133-136 (1997). [pdf file]

8. MacMillan, A.M.; Query, C.C.; Allerson, C.A.; Chen, S.; Verdine, G.L.; Sharp, P.A. "Dynamic Association of Proteins with the pre-mRNA Branch Region" Genes Dev., 8 3008-3020 (1994). [pdf file]

7. Chen, L.; MacMillan, A.M.; Verdine, G.L. "Mutational Separation of DNA Binding from Catalysis in a DNA Cytosine Methyltransferase" J. Am. Chem. Soc., 115 5318-5319 (1993). [pdf file]

6. MacMillan, A.M.; Lee, R.J.; Verdine, G.L. "Direct Observation of a Specific Contact in the l Repressor-OL1 Complex by Isotope-edited NMR" J. Am. Chem. Soc., 115 4921-4922 (1993). [pdf file]

5. MacMillan, A.M.; Chen, L.; Verdine, G.L. "Synthesis of an Oligonucleotide Suicide Substrate for DNA Methyltransferases" J. Org. Chem., 57 2989-2991 (1992). [pdf file]

4. Chen, L.; MacMillan, A.M.; Chang, W.; Ezaz-Nikpay, K.; Lane, W.S.; Verdine, G.L. "Direct Identification of the Catalytic Nucleophile in a DNA Methyltransferase" Biochemistry, 30 11018-11025 (1991). [pdf file]

3. MacMillan, A.M.; Verdine, G.L. "Engineering Tethered DNA Molecules by the Convertible Nucleoside Approach" Tetrahedron, 47 2603-2616 (1991). [pdf file]

2. MacMillan, A.M.; Verdine, G.L. "Synthesis of Functionally Tethered Oligonucleotides by the Convertible Nucleoside Approach" J. Org. Chem., 55 5931-5933 (1990). [pdf file]

1. Brook, A.G.; MacMillan, A. "Silacyclopropanes from the Reaction of Silenes with Wittig Reagents" J. Organomet. Chem., 341 C9-C12 (1988). [pdf file]